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apalutamide will reduce the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with medicine which have been CYP3A4 substrates can lead to reduced publicity to those drugs.Together with the removal of surplus air and